Yamamoto Nutrition Mega SAUZER is a food supplement based on citrulline, beta alanine and arginine alpha-ketoglutarate, with taurine, branched chain amino acids (BCAA), vitamins C, B6 and B12 and plant extracts, with caffeine and other nutritional factors. The product is suitable for adult athletes who practice intense physical activity, such as pre-workouts. The branched chain amino acids are indicated for the integration of the sportsman's diet. Vitamins C, B6 and B12 contribute to the reduction of tiredness and fatigue and to normal energy-yielding metabolism, while vitamin B6 also contributes to normal protein and glycogen metabolism. The release of the new version of Shura KHAN has projected the pre-workout supplements without stimulants into a new generation, but has opened up the use and diffusion of raw materials of the highest quality (many of which are patented) and with proven efficacy. That's why, on the enthusiastic wave of the Shura KHAN, the Mega SAUZER returns in a new guise. Reformulated and renewed, the "historic" king of the Yamamoto® pre-workout line returns with the addition of elements that will enhance its already known qualities. Three in particular are its strengths, the stimulation of nitric oxide, the ergoenic-adrenergic stimulation and the most recent addition, nootropic to ensure a lucid focus on unprecedented training. Objective: the formulation of supplements that really work, and always improve, thanks to the most real scientific research supported by the needs of the athlete, and to the most qualitative certified raw materials. To favor the maximum blood flow and therefore a better transport of oxygen and nutrients to the muscles, Citrulline malate is present as a great protagonist, of which the characteristics of which are now well known that place it among the most effective elements that stimulate nitric oxide, even compared to the same arginine. In this regard, I always want to emphasize that after oral intake, arginine is subject to extensive pre-systemic and systemic elimination, due to the intervention of intestinal bacteria and hepatic and intestinal arginases which convert it into ornithine and urea.

These factors significantly reduce the amount of arginine available for the synthesis of nitric oxide and for the other functions for which it is responsible, limiting the effectiveness of a specific oral integration of arginine much appreciated in the past but still present in a " outdated" and often overrated for the purposes assumed. On the other hand, the amino acid Citrulline is not subject to the pre-systemic and first-pass elimination just described, and can be converted first into argininosuccinate, then into arginine, thus acting as a precursor of this amino acid. The administration of citrulline significantly increases both the plasma levels of arginine and those of citrulline in a dose-dependent manner, and with the same dosage and route of administration (by mouth), citrulline would guarantee an increase in blood arginine levels almost double compared to the same dose of slow-dose arginine, and about 20% higher than those of the same dose of immediate-release arginine. All in favor of a powerful stimulation of blood flow to the muscles engaged in training. Citrulline salified with malic acid has demonstrated in several scientific studies a positive effect in the production of muscle ATP by increasing the efficiency of the energy produced, with a decrease in the phosphocreatine depletion rate reduced by 28% and an accelerated recovery rate of 20%. Already appreciated as a performance-oriented supplement for the aforementioned reasons, it has several advantages in terms of the extension and quality of performance, such as for example that of buffering the accumulation of ammonia (responsible for the onset of fatigue by inhibiting the conversion of pyruvate to acetyl-CoA by hindering muscle contraction). Another benefit of Citrulline Malate would be to decrease muscle soreness following high intensity muscle exercise, which when coupled with the strongly promoting muscle pump, lactate buffering and increased rate of phosphocreatine replenishment, will an excellent ally to improve the performance of our training but also for a more efficient recovery. And we know that the sooner you recover, the sooner and better you get back to training. L-Arginine has not been completely eliminated, but is present in the form of AAKG ARGININE-ALFA-KETOGLUTARATE, which is a form of arginine linked to Alpha ketoglutarate, which is a very important ketoacid at the metabolic level.being the intersection point between anabolic and catabolic reactions. This association improves the stability of arginine in an aqueous environment, and improves its ergogenic capacity, by intervening in the Krebs cycle.

The AAKG is obviously involved in supporting the activity of Citrulline, in the synthesis of NO which, in turn, will favor vasodilation, and facilitating the supply of oxygen and nutrients to the tissues at the muscle level, allowing you to maintain longer and more intensely muscle pumping and performance during the training session. Always looking for maximum performance in "every" workout, another element in the team is beta-alanine, capable of facilitating high-intensity workouts, supporting greater amounts of anaerobic training, enhancing endurance and delaying muscle fatigue , contributing to the optimization of workouts, especially short and intense ones thanks to the increase in carnosine reserves in the muscles. Known for years in the world of sports supplements (both for anaerobic and aerobic work) it also helps maintain optimal muscle pH during exercise by buffering the action of lactic acid. Finally, beta-alanine would also be able to improve ventilation under stress, reducing fatigue and further contributing to the execution of high-intensity workouts. If the maximum pump is the goal of this supplement, another first choice element that we wanted to include is L-Norvaline, a water-soluble amino acid that derives from L-Valine. A precious amino acid due to the endogenous concentration of arginine within the body, thus capable of maximizing the production of nitric oxide. The peculiarity of Norvalina is to extend the production of nitric oxide thanks to the stop of the activity of arginase, the enzyme that removes arginine and converts it into urea and limits the production of nitric oxide. Thus we will have more stock made more bioavailable of arginine, thus making Norvaline a valuable teammate with Citrulline and AAKG. More blood transported allows the support of greater oxygenation to the muscles and the delivery of precious bioavailable nutritional elements for reconstruction and recovery such as the branched chain amino acids Leucine, Valine, Isoleucine. Ultra studied and with more than recognized qualities, branched chain amino acids have particular characteristics: they make the nitrogen balance positive, demonstrating the ability to obtain significant modifications of the amino acid profile even in proteocatabolic situations, stimulating protein synthesis. They are catabolised directly by the skeletal muscle, therefore their metabolism does not considerably involve the liver (Leucine, on the contrary, plays an inhibitory role in the formation of urea in the liver) and it is for this reason that BCAAs are prescribed to patients with hepatic. What can we say, physiologically speaking they make up about 20% of muscle proteins, but their importance is not only from a plastic point of view, i.e. as simple precursors of protein molecules, but they are also indispensable for the synthesis of muscle proteins, effect " anabolic" which is mainly due to the "queen of amino acids" Leucine. We recall that in muscle and liver protein synthesis is slowed down during intense and protracted muscle work, and also during the first phase of recovery, while degradation is accelerated. This situation is a consequence of a set of cascading factors such as the decrease in blood concentration of insulin and an increase in that of catecholamines. In the second phase of recovery the proteins are reconstructed and the amino acids captured by the blood are 90% branched, this is because the catabolism during physical exercise occurs above all at the expense of the latter; in this phase the BCAAs, thanks to their property of stimulating protein synthesis, favor the recovery from fatigue caused by catabolism. It is no coincidence that they are included in pre and during workout blends in particular also for their energy function: the administration of branched chain amino acids during intense and prolonged physical activity should meet the increased demand for Alanine and the availability of BCAAs of origin exogenous would make it possible to limit the consumption of those of endogenous origin, thus decreasing the autolysis of muscle proteins during work with a considerable advantage for physical efficiency and level of performance,delaying the onset of fatigue thanks to the competition in the absorption at the level of the blood-brain barrier with Tryptophan (precursor amino acid of the formation of serotonin, hormone responsible for the feeling of drowsiness, decreased attention and sense of fatigue).

As stimulating element is caffeine, the most widespread and most consumed psychoactive substance in the world that interacts with specific biological receptors that regulate the functions of the endocrine cardiovascular system, as well as the nervous system, increasing energy levels, times reactions become more efficient, also improving the perception of the pain threshold and allowing a "sharper" concentration. In addition to the well-known ergogenic effect, we should mention the "metabolic" one, as fatty acids are mobilized when we consume caffeine, thus saving precious muscle glycogen. This allows the athlete to train for longer, and the saving of glycogen seems to occur in the first fifteen minutes of the activity, a period in which the use of glycogen decreases by 50%.

Another highly stimulating element that contains the new Mega Sauzer is Korean Ginseng. Known and used for millennia, this adaptogen par excellence has a high content of Ginsenosides Rg1 which makes it particularly stimulating.

Its benefits have been known for thousands of years, in popular circles, in oriental traditions. However, they began to be the subject of real scientific studies only during the Second World War: the Soviet Ministry of Defense was looking for substances that would increase the resistance of its soldiers. Why was it included in a preworkout blend for body builders? The qualities are many and the work it can do with the other elements is well synergistic as it helps regulate breathing during sporting activity, allowing not only energy saving but also an improvement in strength and endurance on high volume workouts , improves reflexes and reduces mental fatigue, promotes cardiovascular work, it is believed that it also acts in favor of the muscles of athletes thanks to its ability to promote the release of creatine, and helps eliminate waste substances from the body by lowering the accumulation of lactic acid in the blood following intense physical activity.

Speaking of "adaptogens", an element of great value for our pre-workout is Rhodiola. The well-known phytotherapeutic extract whose adaptogenic properties have been attributed to two of its active ingredients, para-tyrosol and salidroside, which influence the levels of some mediators in the brain and peripheral, cardiovascular and respiratory tissues, reducing the secretion of catabolic hormones such as cortisol. It has in fact been demonstrated that Rosavin, by activating an enzyme, adenylate cyclase at the level of fat cells, promotes the release of fatty acids from the blood. The mobilization of these determines an increase of energy substrate for the production of ATP which will be available for the muscular needs which has re-launched its fame also in the sporting world. As a consequence, there is an improvement in physical performance and an increase in resistance to fatigue, further support for those seeking maximum performance. For body builders, we recall that Rhodiola boasts the ability to reduce the onset of DOMS (delays onset muscle soreness), after intense exercise, thus facilitating post-work-out muscle recovery, to reduce post concentrations of damage markers muscle such as myoglobin, creatine kinase and lactate dehydrogenase, thus validating the much-cited myoprotective role and optimizes the mitochondrial energy flow. But the great innovation that we have also included in the new formulation of Mega SAUZER is Cognizin. With the stimulating action of Caffeine and Korean Ginseng, like the new Shurakhan, the Mega Sauzer will boast a highly effective natural nootropic substance to favor maximum lucidity and focus in training. A Kyowa patent based on fermented Citicoline, supported by several very interesting clinical studies, is a natural precursor of one of the most important neurotransmitters in the brain, acetylcholine, in other words it helps regulate the transmissions between neurons in the brain, dedicating itself to thought process and increasing memory functions. Cognizin helps increase the activity of mitochondria in brain cells, powerful powerhouses of the brain, promoting better focus, learning,increased memory and better general brain function. It has also been seen to increase the levels of dopamine and norepinephrine, two neurotransmitters that are both linked to mood and memory, which we know undergo various oscillations at certain times for the agonist.

Dopamine helps control both mood and movement, and its level increases lead to a rise in mood more predisposed towards pleasure and positivism, as well as essential for memorizing new memories and learning new experiences. Norepinephrine helps control the fight or flight reaction that can be triggered by the adrenal glands in times of stress in the athlete. Excellent "brain nourishment" to encourage the search for that "mind-muscles connection" in training and its maximum concentration, also thanks to which it brings this pre-workout blend to yet another new innovative dimension signed by Yamamoto Nutrition.